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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 15.15
Human Site: S567 Identified Species: 20.83
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S567 E P M K A F D S R F T E R S K
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S567 E P M K A F D S R F T E R S K
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S688 E P M K A F D S R F T E R S K
Dog Lupus familis XP_543550 1017 111618 S567 E P M K A F D S R F T E R S K
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 R567 P M K A F D S R F T E R S K A
Rat Rattus norvegicus NP_001129232 1015 111665 R567 P M K A F D S R F T E R S K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 P567 T T P S K I E P M K A F D S R
Frog Xenopus laevis Q8QFR2 1013 112021 F567 M K A L D S R F T E R S K A T
Zebra Danio Brachydanio rerio XP_696478 1010 111223 S567 D S R F T E R S K A T P G V T
Tiger Blowfish Takifugu rubipres O42611 1025 111838 R567 L D S R F T E R S K A T P G A
Fruit Fly Dros. melanogaster O17468 1047 113397 L564 S E F V K A A L D Y R L H V S
Honey Bee Apis mellifera XP_001122939 838 91355 T413 N T N L H P P T T T A T T P A
Nematode Worm Caenorhab. elegans Q09589 935 103412 P510 A K R K A L A P A V P A K K G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 N539 G S N S N S N N C G V K D R T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 R567 K V P G T S G R D G V L N V E
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 F415 V D K D S L D F P E S I N Q L
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 V565 N K R K A V I V E D E E E E E
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 0 0 N.A. N.A. 6.6 0 13.3 0 0 0 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 0 0 N.A. N.A. 20 13.3 26.6 13.3 6.6 6.6 20 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 0 N.A. 0 6.6 20
P-Site Similarity: N.A. 20 N.A. 13.3 20 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 6 12 36 6 12 0 6 6 18 6 0 6 24 % A
% Cys: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % C
% Asp: 6 12 0 6 6 12 30 0 12 6 0 0 12 0 0 % D
% Glu: 24 6 0 0 0 6 12 0 6 12 18 30 6 6 12 % E
% Phe: 0 0 6 6 18 24 0 12 12 24 0 6 0 0 0 % F
% Gly: 6 0 0 6 0 0 6 0 0 12 0 0 6 6 6 % G
% His: 0 0 0 0 6 0 0 0 0 0 0 0 6 0 0 % H
% Ile: 0 0 0 0 0 6 6 0 0 0 0 6 0 0 0 % I
% Lys: 6 18 18 36 12 0 0 0 6 12 0 6 12 18 24 % K
% Leu: 6 0 0 12 0 12 0 6 0 0 0 12 0 0 6 % L
% Met: 6 12 24 0 0 0 0 0 6 0 0 0 0 0 0 % M
% Asn: 12 0 12 0 6 0 6 6 0 0 0 0 12 0 0 % N
% Pro: 12 24 12 0 0 6 6 12 6 0 6 6 6 6 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % Q
% Arg: 0 0 18 6 0 0 12 24 24 0 12 12 24 6 6 % R
% Ser: 6 12 6 12 6 18 12 30 6 0 6 6 12 30 6 % S
% Thr: 6 12 0 0 12 6 0 6 12 18 30 12 6 0 18 % T
% Val: 6 6 0 6 0 6 0 6 0 6 12 0 0 18 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _